The study of ER stress regulator, BAX Inhibitor-1-associated cancer metastasis In this investigation our focus was to understand the critical characteristics of BAX Inhibitor-1 or Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) as a cancer metastasis-associated protein. Under this we have taken studies on

BI-1 controls CYP2E1 expression and is associated with NADPH-dependent CYP reductase(CPR), reducing the activity of CYP2E1 and the releasable Ca2+ from ER.

In Diabetes pathophysiology, we have a purpose to document the role of ER stress and its associated mechanism. Through this study, we want to suggest therapeutic strategy and understanding for diabetes and it complications.

To study cardiac ischemia-ROS and ER stress in diabetic cardiovascular diseases? To suggest ER stress regulator mechanism in diabetes complication diseases-associated cell system ? To apply active compounds for diabetic complication diseases The study of ER stress and its regulator in diabetic complication diseases.

In this study, anti-cancer agent candidates would be developed based upon the accumulated data of BI-1 protein, itself. Also, BI-1 basic function was studied and chemical library was used for the development of BI-1 antagonist.

Aimed to understand the stress signaling's meaning and pathways through the degradation of protein disulphide isomerase (PDI), a representative stress responsive chaperone protein.

To understand the IRE-1α Signaling and its cross link with the ER stress which will lead us to development of ER stress platform.