One of the Leading Research laboratory
About Research
“The research investigations in our laboratory focuses on Endoplasmic Reticulum (ER) stress/unfolded protein response (UPR)”
Focus : Our laboratory focuses on Endoplasmic Reticulum stress protein response
The UPR provides a flexi system that allows the cells to meet the necessary physiological demands on the ER.

The research investigations in our laboratory focuson endoplasmic reticulum (ER) stress/unfolded protein response (UPR). The UPR provides a flexi system that allows the cells to meet the necessary physiological demands on the ER. Still, dozens of investigations focus/press on the role of ER stress and UPR functioning in the development and progression of pathology of diverse diseases. Our research group focuses on ER stress signal transduction pathways involved in transducing the unfolded protein signal from the ER to other cellular organelles- mitochondria, nucleus, lysosomes or the cytosol. Additionally, ER stress response, ER-calcium disturbance were analyzed with a view of disease applications. On the other side/hand, diabetes, hypertension, cancer, NAFLD, depression and fibrosis are focused with an objective of understanding the ER response. Upon addressing the ER stress signal transduction pathways through in vitro and in vivo assays, we look forward for development of potential medicines. Also, from the past 10 years, we are striving hard to understand the role of Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) and its association with cancer, ER stress, etc. Now, we are going extra mile to understand it by focusing on the TMBIM1-6 family.

Achievements
ER stress lab well known for scientific contribution in republic of Korea and we have several reputed publications under our name. Also, we are awarded with several domestic patents and few are waiting to be submitted for American patent.
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Projects
Our projects

ER Stress Regulator

The study of ER stress regulator, BAX Inhibitor-1-associated cancer metastasis In this investigation our focus was to understand the critical characteristics of BAX Inhibitor-1 or Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) as a cancer metastasis-associated protein.

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Development of diabetic vascular complication

In Diabetes pathophysiology, we have a purpose to document the role of ER stress and its associated mechanism. Through this study, we want to suggest therapeutic strategy and understanding for diabetes and it complications

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Food material-regulated Insulin resistance by ER stress

In type II DM, insulin resistance is one of important factors to explain the mechanism. In addition, the maintenance of blood high glucose induces pancreatic damage and liver overload.

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Discovery of anti-metastasis of cancer

In the presence of the chemicals, mitochondria function can be affected in BI-1-overexpressing cells: This is our hypothesis. Under the hypothesis, we searched the chemicals which are regulating the BI-1-induced mitochondrial alteration.

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Study of cardiac cytochrome P450 and BAX inhibitor

Overexpressed Bax inhibitor-1 (BI-1) provides protection against apoptosis induced by some types of stimuli especially ischemia-reperfusion (I/R) injury in brain.

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Mechanism of IGF-1-induced protective effect on adriamycin-induced apoptosis

Adriamycin is an anthracycline derivative and is one of the most frequently used antineoplastic agnets in the treatment of leukemias and solid tumors.

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About ER Lab Facilities
Our research laboratory has well equipped research lab and facilities at its disposal, of which some of the equipments are unique to the lab in the medical school of the university.
Along with these unique laboratory-level equipments, we have state-of-the-art facility for animal experiments involving animals like mice, rats, rabbits and zebra fishes for better understanding through in vivo investigations. Lab is equipped with advanced instruments such as confocal microscope, protein purification systems, real-time PCR, etc. Additionally, lab has access to electron microscope, advanced chromatography systems, etc upon request.
Our Network
Building network is valuable as it speeds up progress and enhances the quality of research. Additionally, it encourages creativity among the researchers as well as skill development along with idea generation. We believe that Science needs to be discussed and shared, without discussion and sharing science will not grow. As we believe in understanding research of others as well as discuss our research with scientific community building scientific rapport between the institutes which will contribute to science.
Currently, we are collaborated with many domestic and international institutes and also interested in development of research network with institutes for better contribution to scientific world. Academic and research collaboration is a very valuable tool that not only accelerates the progress but also enhances the quality of the work and extends the repertoire of the partners.
PUBLICATIONS
Bhattarai, K.R.
"Endoplasmic Reticulum (ER) Stress Response Failure in Diseases. Trends Cell Biol, 2020. 30(9): p. 672-675."
Kim, H.K.
"TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation. Nat Commun, 2020. 11(1): p. 4012."
Kim, H.K.
"TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy, 2020: p. 1-18."
Lee, G.H.
"Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients, 2020. 12(3)."
Lee, H.Y.
"Ixeris dentata and Lactobacillus gasseri Extracts Improve Salivary Secretion Capability in Diabetes-Associated Dry Mouth Rat Model. Nutrients, 2020. 12(5)."
Lee, H.Y.
"The correlation of IRE1alpha oxidation with Nox4 activation in aging-associated vascular dysfunction. Redox Biol, 2020. 37: p. 101727."
Lee, H.Y.
"Phosphatidylinositol 3-kinase-delta controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice. Br J Pharmacol, 2020. 177(7): p. 1556-1567."
Park, S.A.
"Glucose-lowering effect of Gryllus bimaculatus powder on streptozotocin-induced diabetes through the AKT/mTOR pathway. Food Sci Nutr, 2020. 8(1): p. 402-409."
Riaz, T.A.
"Role of Endoplasmic Reticulum Stress Sensor IRE1alpha in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation. Cells, 2020. 9(5)."
Lee, H. Y., Lee, G. H., Yoon, Y., and Chae, H. J. (2019)
"Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation, Am J Chin Med 47, 1253-1270."
Junjappa, R. P., Kim, H. K., Park, S. Y., Bhattarai, K. R., Kim, K. W., Soh, J. W., Kim, H. R., and Chae, H. J. (2019)
"Expression of TMBIM6 in Cancers: The Involvement of Sp1 and PKC, Cancers (Basel) 11."
Lee, G. H., Hoang, T. H., Jung, E. S., Jung, S. J., Chae, S. W., and Chae, H. J. (2019)
"Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats, Nutrients 11."
Park, S., Nhiem, N. X., Park, J. H., Bhattarai, K. R., Chae, H. J., Kim, H. R., and Kim, S. H. (2019)
"Isolation of amylase regulators from the leaves of Ixeridium dentatum, Nat Prod Res, 1-6."
An, A. R., K. M. Kim, H. S. Park, K. Y. Jang, W. S. Moon, M. J. Kang, Y. C. Lee, J. H. Kim, H. J. Chae and M. J. Chung (2019).
"Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer."
J Pathol Transl Med.
Aryal, Y. P., S. Neupane, N. Adhikari, C. H. An, J. H. Ha, T. Y. Kwon, H. Yamamoto, J. K. Jung, E. K. Park, J. Y. Kim, S. W. Cho, W. J. Sohn, Y. Lee, H. J. Chae, H. R. Kim and J. Y. Kim (2019).
"An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar." J Cell Physiol.
J Pathol Transl Med.
Bhandary, B., A. Marahatta, H. R. Kim and H. J. Chae (2012).
"An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases." Int J Mol Sci 14(1): 434-456.
Bhattarai, K. R., R. Junjappa, M. Handigund, H. R. Kim and H. J. Chae (2018).
"The imprint of salivary secretion in autoimmune disorders and related pathological conditions." Autoimmun Rev 17(4): 376-390.
Bhattarai, K. R., H. R. Kim and H. J. Chae (2018).
"Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors." Int J Med Sci 15(8): 823-831.
Han, Y. H., S. Y. Kwon, J. Kim, C. J. Na, S. Choi, J. J. Min, H. S. Bom, Y. C. Kim, I. J. Oh, H. J. Chae, S. T. Lim, M. H. Sohn and H. J. Jeong (2015).
"A phase II clinical trial to investigate the effect of pioglitazone on (18)F-FDG uptake in malignant lesions." EJNMMI Res 5(1): 50.
Jin, C. F., B. Li, S. M. Lin, R. K. Yadav, H. R. Kim and H. J. Chae (2013).
"Mechanism of the Inhibitory Effects of Eucommia ulmoides Oliv. Cortex Extracts (EUCE) in the CCl 4 -Induced Acute Liver Lipid Accumulation in Rats." Int J Endocrinol 2013: 751854.
Junjappa, R. P., P. Patil, K. R. Bhattarai, H. R. Kim and H. J. Chae (2018).
"IRE1alpha Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases." Front Immunol 9: 1289.
Khan, M. M., B. Q. Tran, Y. J. Jang, S. H. Park, W. E. Fondrie, K. Chowdhury, S. H. Yoon, D. R. Goodlett, S. W. Chae, H. J. Chae, S. Y. Seo and Y. A. Goo (2017).
"Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects." Mol Cells 40(7): 466-475.
Kim, H. J., K. H. Park, D. H. Kim, H. J. Chae, G. H. Sung and Y. O. Kim (2018).
"In vitro assessments of bone microcomputed tomography in an aged male rat model supplemented with Panax ginseng." Saudi J Biol Sci 25(6): 1135-1139.
Kim, H. K., G. H. Lee, K. R. Bhattarai, R. P. Junjappa, H. Y. Lee, M. Handigund, A. Marahatta, B. Bhandary, I. H. Baek, J. S. Pyo, H. K. Kim, O. H. Chai, H. R. Kim, Y. C. Lee and H. J. Chae (2018).
"PI3Kdelta contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-kappaB axis." Exp Mol Med 50(2): e444.
Kim, H. K., R. K. Yadav, K. R. Bhattarai, H. W. Jung, H. R. Kim and H. J. Chae (2018).
"Transmembrane BAX Inhibitor Motif-6 (TMBIM6) protects against cisplatin-induced testicular toxicity." Hum Reprod 33(3): 378-389.
Kim, H. K., C. Zhao, B. R. Choi, H. J. Chae, D. S. Kim and J. K. Park (2013).
"Is transforming growth factor-beta signaling activated in human hypertrophied prostate treated by 5-alpha reductase inhibitor?" Dis Markers 35(6): 679-685.
Kim, J. H., M. S. Kim, H. G. Oh, H. Y. Lee, J. W. Park, B. G. Lee, S. H. Park, D. I. Moon, E. H. Shin, E. K. Oh, M. Erkhembaatar, O. Kim, Y. R. Lee and H. J. Chae (2013).
"Treatment of eggshell with casein phosphopeptide reduces the severity of ovariectomy-induced bone loss." Lab Anim Res 29(2): 70-76.
Kim, T. S., Y. H. Shin, H. M. Lee, J. K. Kim, J. H. Choe, J. C. Jang, S. Um, H. S. Jin, M. Komatsu, G. H. Cha, H. J. Chae, D. C. Oh and E. K. Jo (2017).
"Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway." Sci Rep 7(1): 3431.
Lee, G. H., T. H. Hoang, E. S. Jung, S. J. Jung, S. W. Chae and H. J. Chae (2019).
"Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats." Nutrients 11(5).
Lee, G. H., H. R. Kim and H. J. Chae (2014).
"BI-1 enhances Fas-induced cell death through a Na+/H+-associated mechanism." BMB Rep 47(7): 393-398.
Lee, G. H., H. Y. Lee, M. K. Choi, A. H. Choi, T. S. Shin and H. J. Chae (2018).
"Eucommia ulmoides leaf (EUL) extract enhances NO production in ox-LDL-treated human endothelial cells." Biomed Pharmacother 97: 1164-1172.
Lee, G. H., H. Y. Lee, M. K. Choi, H. W. Chung, S. W. Kim and H. J. Chae (2017).
"Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress." BMC Res Notes 10(1): 77.
Lee, G. H., H. Y. Lee, B. Li, H. R. Kim and H. J. Chae (2014).
"Bax inhibitor-1-mediated inhibition of mitochondrial Ca2+ intake regulates mitochondrial permeability transition pore opening and cell death." Sci Rep 4: 5194.
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