The research investigations in our laboratory focuson endoplasmic reticulum (ER) stress/unfolded protein response (UPR). The UPR provides a flexi system that allows the cells to meet the necessary physiological demands on the ER. Still, dozens of investigations focus/press on the role of ER stress and UPR functioning in the development and progression of pathology of diverse diseases. Our research group focuses on ER stress signal transduction pathways involved in transducing the unfolded protein signal from the ER to other cellular organelles- mitochondria, nucleus, lysosomes or the cytosol. Additionally, ER stress response, ER-calcium disturbance were analyzed with a view of disease applications. On the other side/hand, diabetes, hypertension, cancer, NAFLD, depression and fibrosis are focused with an objective of understanding the ER response. Upon addressing the ER stress signal transduction pathways through in vitro and in vivo assays, we look forward for development of potential medicines. Also, from the past 10 years, we are striving hard to understand the role of Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) and its association with cancer, ER stress, etc. Now, we are going extra mile to understand it by focusing on the TMBIM1-6 family.