Adriamycin is an anthracycline derivative and is one of the most frequently used antineoplastic agnets in the treatment of leukemias and solid tumors. However, severe cardiotoxicity of adriamycin is a major limiting factor for its effective use in the treatment of all malignancies.
In this study, we show role of factors acting downstream of PI3K. We identify mitochondria-dependent mechanism responsible for antiapoptotic properties of IGF-1.