In this investigation our focus was to understand the critical characteristics of BAX Inhibitor-1 or Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) as a cancer metastasis-associated protein. Under this we have taken studies on
BI-1 controls CYP2E1 expression and is associated with NADPH-dependent CYP reductase(CPR), reducing the activity of CYP2E1 and the releasable Ca2+ from ER.
BI-1 controls the hyperoxidation of protein disomerase (PDI), ER redox chaperone, reducing ROS accumulation where BI-1 enhances PDI-client proteins? Folding.
BI-1 enhances lysosomal Ca2+ maintenance concentration through leaky Ca2+ from ER, leading to autophagy. In macro RNA analysis, we have showed that the presence of BI-1 increases the expression of glucose metabolism and cancer metastasis.